THE BIG NEWS IS MICROSPHERES.

ZILRETTA is the first and only FDA-approved treatment for osteoarthritis knee pain to use extended-release microsphere technology.

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What’s so special about these microspheres?

They’re tiny particles that are so small, they cannot be seen by the naked eye. They contain a medicine called triamcinolone acetonide, which helps reduce pain and inflammation caused by osteoarthritis.

Once injected directly into the knee, the microspheres stay put, slowly and continually releasing their medicine for about 3 months.

That’s big.

Staying power

ZILRETTA microspheres stay right in your knee joint—right where the pain is.

After releasing all their medicine into the knee joint, the microspheres break down and turn into carbon dioxide and water, which are naturally found in the body.

Image of blue spheres (representative of microsphere technology) Text read: Actual microspheres are not visible to the naked eye

ZILRETTA microspheres slowly release pain medication into the knee joint for about 3 months

Image shows a multitude of blue spheres over a timeline that starts at injection day and goes up to month one, two, and three

Image shows a multitude of blue spheres over a timeline that starts at injection day and goes up to month one, two, and three

See how ZILRETTA microsphere technology works

Icon representative of a drop of blood being analyzed

News for people with Type 2 diabetes

In a small clinical trial of people with controlled Type 2 diabetes, minimal elevation in their blood glucose level was experienced after treatment with ZILRETTA vs another corticosteroid.

Note: Corticosteroids may increase blood glucose levels. Individual patient experience may differ from what was seen in this study.

The clinical significance of this information is unknown.

See how ZILRETTA worked for these five people

See more stories and videos here

One injection. Three months of major knee pain relief is possible. Ask about the Z!

Indication and Important Risk Information

What is ZILRETTA?
ZILRETTA^® (triamcinolone acetonide extended-release injectable suspension) is an extended-release corticosteroid approved to manage osteoarthritis knee pain. The benefits and risks of repeat injections have not been demonstrated.

Who should not receive ZILRETTA?
You should not receive a ZILRETTA injection if you are allergic to corticosteroids, triamcinolone acetonide, or any other component of the product.

What possible side effects of corticosteroids could occur with ZILRETTA?

Rare serious allergic reactions
Effects in the injected knee such as infection (with pain, swelling and restricted motion) or joint damage
Increased chance of getting an infection, and a decreased ability to fight an infection
Effects on hormone production. These effects can be reversible
Elevated blood pressure, sodium and water retention, and potassium loss
Intestinal perforation if you have certain gastrointestinal disorders
Weakening of bones
Changes in behavior or mood disturbances
Increased pressure inside the eye

What are the most common side effects of receiving a ZILRETTA injection?
In multiple clinical trials, the most common side effects seen in people taking ZILRETTA were joint pain, headache, joint swelling, back pain, sore throat and runny nose, upper respiratory tract infection, and bruising.

What should you tell your doctor BEFORE receiving a ZILRETTA injection?
Tell your doctor about all of the medications you are taking (including both prescription and over-the-counter medicines) and about any medical conditions, especially if you have high blood pressure, heart disease, ulcers, diverticulitis or other gastrointestinal disorders, kidney problems, diabetes, glaucoma, behavior or mood disorders, and/or infections.

What should you tell your doctor AFTER receiving a ZILRETTA injection?
Contact your doctor if you develop a fever or other signs of infection, have an increase in pain along with swelling of the injected knee, restriction of joint motion, or a general feeling of discomfort. Contact your doctor immediately if you are exposed to chicken pox or measles, or for any new or worsening changes in behavior or mood.

These are not all of the possible side effects with ZILRETTA or corticosteroid medications. Please see the full Prescribing Information at www.ZILRETTALabel.com/PI.pdf. Always contact your doctor if you have questions or experience any side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.