Have osteoarthritis of the knee?

This could be just what your knee needs!

You may now want to ask your healthcare provider about ZILRETTA™ (triamcinolone acetonide extended-release injectable suspension). New ZILRETTA is the first and only FDA-approved treatment for osteoarthritis knee pain using extended-release microsphere technology.

Don't grin and bear knee pain.



A new knee pain relief treatment is here!

New ZILRETTA is a non-opioid extended-release pain relief treatment that was studied in multiple trials on hundreds of patients who have osteoarthritis of the knee.

In the main clinical trial, some people were injected with ZILRETTA, while others were injected with saltwater. People were asked to rate their knee pain on a daily basis, and results were compared between the two groups.

Ask your healthcare provider how the Z could help your knee.


The Big News Is Microspheres

ZILRETTA is the first and only FDA-approved treatment that uses extended-release microsphere technology to treat osteoarthritis of the knee.

Microspheres are so tiny they cannot be seen by the naked eye, and contain medicine called triamcinolone acetonide. Once injected directly into the knee joint, the microspheres stay put, slowly and continually releasing their medicine over time, for about 3 months.

After they have released all their medicine into the knee joint, the microspheres break down and turn into carbon dioxide and water, which are found naturally in the body.

Ask your healthcare provider about giving your knee the Z.

One injection. An entire season of relief. Ask about the Z!

Indication and Important Risk Information

ZILRETTA™ (triamcinolone acetonide extended-release injectable suspension) is an extended-release corticosteroid approved to manage osteoarthritis knee pain. It is not intended for repeat use.

Who should not receive ZILRETTA?
You should not receive a ZILRETTA injection if you are allergic to corticosteroids, triamcinolone acetonide or any other component of the product.

What possible side effects of corticosteroids could occur with ZILRETTA?

  • Rare serious allergic reactions
  • Effects in the injected knee such as infection (with pain, swelling and restricted motion) or joint damage
  • Increased chance of getting an infection, and a decreased ability to fight an infection
  • Effects on hormone production. These effects can be reversible
  • Elevated blood pressure, sodium and water retention, and potassium loss
  • Intestinal perforation if you have certain gastrointestinal disorders
  • Weakening of bones
  • Changes in behavior or mood disturbances
  • Increased pressure inside the eye

What are the most common side effects of receiving a ZILRETTA injection?
In multiple clinical trials, the most common side effects seen in people taking ZILRETTA were joint pain, headache, joint swelling, back pain, sore throat and runny nose, upper respiratory tract infection, and bruising.

What should you tell your doctor BEFORE receiving a ZILRETTA injection?
Tell your doctor about all of the medications you are taking (including both prescription and over-the-counter medicines) and about any medical conditions, especially if you have high blood pressure, heart disease, ulcers, diverticulitis or other gastrointestinal disorders, kidney problems, diabetes, glaucoma, behavior or mood disorders, and/or infections.

What should you tell your doctor AFTER receiving a ZILRETTA injection?
Contact your doctor if you develop a fever or other signs of infection, have an increase in pain along with swelling of the injected knee, restriction of joint motion or a general feeling of discomfort. Contact your doctor immediately if you are exposed to chicken pox or measles, or for any new or worsening changes in behavior or mood.

Please see the full Prescribing Information at www.ZILRETTALabel.com/PI.pdf. Always contact your doctor if you have questions or experience any side effects.

You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.