DON’T GRIN AND BEAR OSTEOARTHRITIS KNEE PAIN.

Suffering doesn’t build character—it just hurts. There is no reward for waiting until it becomes unbearable. But there is a treatment that may help: ZILRETTA – a single injection that can provide major knee pain relief for 3 months.

Down arrow for website navigation

It’s time you said “Enough!”

If you suffer from osteoarthritis of the knee, you know what it means to deal with pain—it is serious. At some point, you realize you face it every day.

Ordinary activities can be truly painful, such as:

Icon of a human figure doing activities that include (from left to right) walking, using stairs, rising, bending at the knee and sleeping

Icon of a human figure doing activities that include (from left to right) walking, using stairs, rising, bending at the knee and sleeping

Give your knee the Z

Not next month. Not next year. Talk to a doctor now.

If you are among the millions of people who suffer needlessly from chronic osteoarthritis knee pain, ZILRETTA may be the injectable, non-opioid pain treatment you’ve been hoping for.

ZILRETTA is the first and only FDA-approved treatment for osteoarthritis knee pain that uses extended-release microsphere technology, studied in multiple clinical trials on hundreds of patients.

ZILRETTA microspheres slowly and continuously release medicine into your knee for about 3 months.

Don’t tolerate knee pain. Give your knee the Z!

Hear why these people decided to try ZILRETTA

See more stories and videos here

One injection. Three months of major knee pain relief is possible. Ask about the Z!

Indication and Important Risk Information

What is ZILRETTA?
ZILRETTA^® (triamcinolone acetonide extended-release injectable suspension) is an extended-release corticosteroid approved to manage osteoarthritis knee pain. The benefits and risks of repeat injections have not been demonstrated.

Who should not receive ZILRETTA?
You should not receive a ZILRETTA injection if you are allergic to corticosteroids, triamcinolone acetonide, or any other component of the product.

What possible side effects of corticosteroids could occur with ZILRETTA?

Rare serious allergic reactions
Effects in the injected knee such as infection (with pain, swelling and restricted motion) or joint damage
Increased chance of getting an infection, and a decreased ability to fight an infection
Effects on hormone production. These effects can be reversible
Elevated blood pressure, sodium and water retention, and potassium loss
Intestinal perforation if you have certain gastrointestinal disorders
Weakening of bones
Changes in behavior or mood disturbances
Increased pressure inside the eye

What are the most common side effects of receiving a ZILRETTA injection?
In multiple clinical trials, the most common side effects seen in people taking ZILRETTA were joint pain, headache, joint swelling, back pain, sore throat and runny nose, upper respiratory tract infection, and bruising.

What should you tell your doctor BEFORE receiving a ZILRETTA injection?
Tell your doctor about all of the medications you are taking (including both prescription and over-the-counter medicines) and about any medical conditions, especially if you have high blood pressure, heart disease, ulcers, diverticulitis or other gastrointestinal disorders, kidney problems, diabetes, glaucoma, behavior or mood disorders, and/or infections.

What should you tell your doctor AFTER receiving a ZILRETTA injection?
Contact your doctor if you develop a fever or other signs of infection, have an increase in pain along with swelling of the injected knee, restriction of joint motion, or a general feeling of discomfort. Contact your doctor immediately if you are exposed to chicken pox or measles, or for any new or worsening changes in behavior or mood.

These are not all of the possible side effects with ZILRETTA or corticosteroid medications. Please see the full Prescribing Information at www.ZILRETTALabel.com/PI.pdf. Always contact your doctor if you have questions or experience any side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.