AN ENTIRE SEASON OF KNEE PAIN RELIEF.

Did you know that there may be a way to reduce osteoarthritis knee pain for 3 months, and maybe more? ZILRETTA may provide the relief you’ve been hoping for.

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ZILRETTA is the first and only FDA-approved treatment for osteoarthritis knee pain that uses extended-release microsphere technology. The main clinical study focused on safety and how well ZILRETTA works. The results? It was shown to reduce osteoarthritis knee pain.

In the clinical trial, some people were injected with ZILRETTA while others were injected with saltwater. People were asked to rate their knee pain on a daily basis, and results were compared between the two groups.

Large text that reads: Zilretta significantly reduced knee pain for 3 months. Small text below reads: What's more, some people treated with Zilretta experienced pain relief beyond 12 weeks through week 16.

Your knee will thank you

In the main clinical study, a single injection of ZILRETTA reduced knee pain for 3 months.

Icon with 7 out of 10 human figures shown in blue, while 3 are shown in pink. Text reads:

Icon with 7 out of 10 human figures shown in blue, while 3 are shown in pink. Text reads:

Just imagine what a season with less knee pain could be like.

See how ZILRETTA worked for these five people

See more stories and videos here

Daily osteoarthritis knee pain can wear down even the strongest person. There’s no reason to suffer needlessly when there is a treatment that could help. Ask your healthcare provider about ZILRETTA.

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One injection. Three months of major knee pain relief is possible. Ask about the Z!

Indication and Important Risk Information

What is ZILRETTA?
ZILRETTA^® (triamcinolone acetonide extended-release injectable suspension) is an extended-release corticosteroid approved to manage osteoarthritis knee pain. The benefits and risks of repeat injections have not been demonstrated.

Who should not receive ZILRETTA?
You should not receive a ZILRETTA injection if you are allergic to corticosteroids, triamcinolone acetonide, or any other component of the product.

What possible side effects of corticosteroids could occur with ZILRETTA?

Rare serious allergic reactions
Effects in the injected knee such as infection (with pain, swelling and restricted motion) or joint damage
Increased chance of getting an infection, and a decreased ability to fight an infection
Effects on hormone production. These effects can be reversible
Elevated blood pressure, sodium and water retention, and potassium loss
Intestinal perforation if you have certain gastrointestinal disorders
Weakening of bones
Changes in behavior or mood disturbances
Increased pressure inside the eye

What are the most common side effects of receiving a ZILRETTA injection?
In multiple clinical trials, the most common side effects seen in people taking ZILRETTA were joint pain, headache, joint swelling, back pain, sore throat and runny nose, upper respiratory tract infection, and bruising.

What should you tell your doctor BEFORE receiving a ZILRETTA injection?
Tell your doctor about all of the medications you are taking (including both prescription and over-the-counter medicines) and about any medical conditions, especially if you have high blood pressure, heart disease, ulcers, diverticulitis or other gastrointestinal disorders, kidney problems, diabetes, glaucoma, behavior or mood disorders, and/or infections.

What should you tell your doctor AFTER receiving a ZILRETTA injection?
Contact your doctor if you develop a fever or other signs of infection, have an increase in pain along with swelling of the injected knee, restriction of joint motion, or a general feeling of discomfort. Contact your doctor immediately if you are exposed to chicken pox or measles, or for any new or worsening changes in behavior or mood.

These are not all of the possible side effects with ZILRETTA or corticosteroid medications. Please see the full Prescribing Information at www.ZILRETTALabel.com/PI.pdf. Always contact your doctor if you have questions or experience any side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.