YOU MAY HAVE PAIN FROM OSTEOARTHRITIS OF THE KNEE.

And it may be telling you it’s time to put a Z in your knee.

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Do any of these thoughts ring true for you?

My pain is consistent, and I need a pain medication that lasts.

I have Type 2 diabetes and I am worried about my osteoarthritis knee pain treatment sharply elevating my blood glucose level.

I want less pain when doing my everyday chores.

I am ready for a new treatment option.

Ordinary activities are truly painful—day and night.

What do people like me have to say about ZILRETTA?

Our Patient Experience Program gathered feedback from patients as they managed their OA knee pain with ZILRETTA. 306 patients with osteoarthritis knee pain, invited to enroll in this survey by their doctors who decided to prescribe them ZILRETTA, reported these results 3 months after their ZILRETTA injection:

OF PATIENTS reported experiencing satisfactory relief from OA after receiving an injection of ZILRETTA

OF PATIENTS indicated that they would recommend ZILRETTA for others with OA knee pain

These results are informational only. Talk with your doctor about all treatment options.

Learn how quickly ZILRETTA can work

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How does osteoarthritis knee pain affect you?

Your doctor wants to know! Fill out this Symptom Summary and bring it with you to your next appointment.

Download Your Symptom Summary

One injection. Three months of major knee pain relief is possible. Ask about the Z!

Indication and Important Risk Information

What is ZILRETTA?
ZILRETTA^® (triamcinolone acetonide extended-release injectable suspension) is an extended-release corticosteroid approved to manage osteoarthritis knee pain. The benefits and risks of repeat injections have not been demonstrated.

Who should not receive ZILRETTA?
You should not receive a ZILRETTA injection if you are allergic to corticosteroids, triamcinolone acetonide, or any other component of the product.

What possible side effects of corticosteroids could occur with ZILRETTA?

Rare serious allergic reactions
Effects in the injected knee such as infection (with pain, swelling and restricted motion) or joint damage
Increased chance of getting an infection, and a decreased ability to fight an infection
Effects on hormone production. These effects can be reversible
Elevated blood pressure, sodium and water retention, and potassium loss
Intestinal perforation if you have certain gastrointestinal disorders
Weakening of bones
Changes in behavior or mood disturbances
Increased pressure inside the eye

What are the most common side effects of receiving a ZILRETTA injection?
In multiple clinical trials, the most common side effects seen in people taking ZILRETTA were joint pain, headache, joint swelling, back pain, sore throat and runny nose, upper respiratory tract infection, and bruising.

What should you tell your doctor BEFORE receiving a ZILRETTA injection?
Tell your doctor about all of the medications you are taking (including both prescription and over-the-counter medicines) and about any medical conditions, especially if you have high blood pressure, heart disease, ulcers, diverticulitis or other gastrointestinal disorders, kidney problems, diabetes, glaucoma, behavior or mood disorders, and/or infections.

What should you tell your doctor AFTER receiving a ZILRETTA injection?
Contact your doctor if you develop a fever or other signs of infection, have an increase in pain along with swelling of the injected knee, restriction of joint motion, or a general feeling of discomfort. Contact your doctor immediately if you are exposed to chicken pox or measles, or for any new or worsening changes in behavior or mood.

These are not all of the possible side effects with ZILRETTA or corticosteroid medications. Please see the full Prescribing Information at www.ZILRETTALabel.com/PI.pdf. Always contact your doctor if you have questions or experience any side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.