GET THE FACTS ABOUT OSTEOARTHRITIS OF THE KNEE.

There’s a lot of information out there, but it may not all be accurate. Below are some common things you may have heard. Can you tell which are true?

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Osteoarthritis of the knee is just pain.

False. Osteoarthritis of the knee is more than pain–it’s a chronic, progressive disease that can get worse over time. It can cause stiffness, swelling, and decreased range of motion. Osteoarthritis may cause you to have difficulty doing the things you love to do, such as walking to the park with your grandchild. It may also impact your ability to do everyday errands, such as bending down to pick up laundry. Learn More

Osteoarthritis of the knee happens to everyone as they age.

False. While many people will develop osteoarthritis of the knee in their lifetime, it does not happen to everyone.

Having osteoarthritis of the knee means I have to stop being active.

False. While you may adjust your level of activity in response to your condition, having osteoarthritis of the knee does not mean you have to cease and desist being active. If you have questions about specific activities, talk to your doctor. But staying active is one of the most important things you can do to help manage osteoarthritis of the knee.

There is nothing I can do for osteoarthritis knee pain.

False. There is no need to suffer. There are numerous treatments for osteoarthritis knee pain. ZILRETTA may be an option. Don’t wait. Talk to your doctor today.

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There is no cure for osteoarthritis of the knee.

True. Osteoarthritis of the knee is a progressive disease that currently has no cure. But treatments such as ZILRETTA can help manage osteoarthritis knee pain.

One injection. Three months of major knee pain relief is possible. Ask about the Z!

Indication and Important Risk Information

What is ZILRETTA?
ZILRETTA^® (triamcinolone acetonide extended-release injectable suspension) is an extended-release corticosteroid approved to manage osteoarthritis knee pain. The benefits and risks of repeat injections have not been demonstrated.

Who should not receive ZILRETTA?
You should not receive a ZILRETTA injection if you are allergic to corticosteroids, triamcinolone acetonide, or any other component of the product.

What possible side effects of corticosteroids could occur with ZILRETTA?

Rare serious allergic reactions
Effects in the injected knee such as infection (with pain, swelling and restricted motion) or joint damage
Increased chance of getting an infection, and a decreased ability to fight an infection
Effects on hormone production. These effects can be reversible
Elevated blood pressure, sodium and water retention, and potassium loss
Intestinal perforation if you have certain gastrointestinal disorders
Weakening of bones
Changes in behavior or mood disturbances
Increased pressure inside the eye

What are the most common side effects of receiving a ZILRETTA injection?
In multiple clinical trials, the most common side effects seen in people taking ZILRETTA were joint pain, headache, joint swelling, back pain, sore throat and runny nose, upper respiratory tract infection, and bruising.

What should you tell your doctor BEFORE receiving a ZILRETTA injection?
Tell your doctor about all of the medications you are taking (including both prescription and over-the-counter medicines) and about any medical conditions, especially if you have high blood pressure, heart disease, ulcers, diverticulitis or other gastrointestinal disorders, kidney problems, diabetes, glaucoma, behavior or mood disorders, and/or infections.

What should you tell your doctor AFTER receiving a ZILRETTA injection?
Contact your doctor if you develop a fever or other signs of infection, have an increase in pain along with swelling of the injected knee, restriction of joint motion, or a general feeling of discomfort. Contact your doctor immediately if you are exposed to chicken pox or measles, or for any new or worsening changes in behavior or mood.

These are not all of the possible side effects with ZILRETTA or corticosteroid medications. Please see the full Prescribing Information at www.ZILRETTALabel.com/PI.pdf. Always contact your doctor if you have questions or experience any side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.