SMALL LIFESTYLE CHANGES CAN MAKE A BIG DIFFERENCE.

Ongoing treatment is just a part of managing osteoarthritis of the knee—having a healthy lifestyle can also help improve your pain symptoms. But you don’t have to change everything overnight. Here are some ways to start small.

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Ways to help manage pain from osteoarthritis of the knee

Get Active

Staying active is one of the best things you can do. Strengthening the muscles around the knee joint can reduce osteoarthritis pain and may help protect the joint against further damage.

Take Charge of Your Health

Visits to your doctor are a time to get the support you need. Make sure your voice is heard. At every appointment, talk about pain and other symptoms, and ask about treatment approaches. You deserve less pain in your life.

Manage Your Weight

Carrying extra weight puts extra strain on your joints; in fact, losing just 1 pound can take 4 pounds of pressure off your knees. Cut calories by making simple food swaps: Trade soda for seltzer or try using low-sodium vegetable or chicken stock instead of oil when pan-frying.

One injection. Three months of major knee pain relief is possible. Ask about the Z!

Indication and Important Risk Information

What is ZILRETTA?
ZILRETTA^® (triamcinolone acetonide extended-release injectable suspension) is an extended-release corticosteroid approved to manage osteoarthritis knee pain. The benefits and risks of repeat injections have not been demonstrated.

Who should not receive ZILRETTA?
You should not receive a ZILRETTA injection if you are allergic to corticosteroids, triamcinolone acetonide, or any other component of the product.

What possible side effects of corticosteroids could occur with ZILRETTA?

Rare serious allergic reactions
Effects in the injected knee such as infection (with pain, swelling and restricted motion) or joint damage
Increased chance of getting an infection, and a decreased ability to fight an infection
Effects on hormone production. These effects can be reversible
Elevated blood pressure, sodium and water retention, and potassium loss
Intestinal perforation if you have certain gastrointestinal disorders
Weakening of bones
Changes in behavior or mood disturbances
Increased pressure inside the eye

What are the most common side effects of receiving a ZILRETTA injection?
In multiple clinical trials, the most common side effects seen in people taking ZILRETTA were joint pain, headache, joint swelling, back pain, sore throat and runny nose, upper respiratory tract infection, and bruising.

What should you tell your doctor BEFORE receiving a ZILRETTA injection?
Tell your doctor about all of the medications you are taking (including both prescription and over-the-counter medicines) and about any medical conditions, especially if you have high blood pressure, heart disease, ulcers, diverticulitis or other gastrointestinal disorders, kidney problems, diabetes, glaucoma, behavior or mood disorders, and/or infections.

What should you tell your doctor AFTER receiving a ZILRETTA injection?
Contact your doctor if you develop a fever or other signs of infection, have an increase in pain along with swelling of the injected knee, restriction of joint motion, or a general feeling of discomfort. Contact your doctor immediately if you are exposed to chicken pox or measles, or for any new or worsening changes in behavior or mood.

These are not all of the possible side effects with ZILRETTA or corticosteroid medications. Please see the full Prescribing Information at www.ZILRETTALabel.com/PI.pdf. Always contact your doctor if you have questions or experience any side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.