DON’T GRIN AND BEAR OA
KNEE PAIN

Give your knee
the Z

ZILRETTA is the first and only FDA-approved treatment for osteoarthritis knee pain that uses extended-release microsphere technology, studied in multiple clinical trials on hundreds of patients.

So, stop tolerating knee pain. Give your knee the Z. Not next month. Not next year. Talk to a doctor now.

What’s so special about ZILRETTA?

It’s the microspheres

They’re tiny particles that are so small, they cannot be seen by the naked eye. Once injected into the knee, the microspheres stay put, slowly and continually releasing medicine for about 3 months.

It’s the staying power

ZILRETTA microspheres stay right in your knee joint—right where the pain is. After releasing all their medicine into the knee joint, the microspheres break down and turn into carbon dioxide and water, which are naturally found in the body.

What’s so special about ZILRETTA?

See how ZILRETTA microsphere technology works

Is it safe?

In clinical studies, ZILRETTA was shown to be generally safe

The most common side effects of ZILRETTA were similar to those seen in people who received a saltwater injection:

  • Joint pain
  • Joint Swelling
  • Sore throat and runny nose
  • Bruising
  • Headache
  • Back pain
  • Upper respiratory tract infection

These are not all of the possible side effects of ZILRETTA. Please see Important Risk Information and the full Prescribing Information. Always contact your doctor if you have questions or experience any side effects.

News for people with

Type 2 diabetes

In a small clinical trial of people with controlled Type 2 diabetes, minimal elevation in their blood glucose level was experienced after treatment with ZILRETTA vs another corticosteroid.

Note: Corticosteroids may increase blood glucose levels. Individual patient experience may differ from what was seen in this study. The clinical significance of this information is unknown.

Results matter

ZILRETTA may provide the relief you’ve been hoping for

In the main clinical study, a single injection of ZILRETTA reduced knee pain for 3 months. What’s more, many people treated with
ZILRETTA experienced pain relief beyond month 3, through month 4.

~70% of study participants had no
to mild knee pain at 3 months

Some patients in this study did not experience a 3-month duration of pain relief.

See what people like you are saying about ZILRETTA

Our Patient Experience Program gathered feedback from patients as they managed their OA knee pain with ZILRETTA. 306 patients
with osteoarthritis knee pain, invited to enroll in this survey by their doctors who decided to prescribe them ZILRETTA, reported these
results 3 months after their ZILRETTA injection:

93% of patients reported
experiencing satisfactory
relief from OA after receiving
an injection of ZILRETTA

88% of patients indicated that
they would recommend
ZILRETTA for others with
OA knee pain

Individual results may vary. Talk with your doctor about all treatment options.

Hear more from actual ZILRETTA patients

Enter your location and see a list of providers who perform ZILRETTA treatments near you.

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